5/22/2025
Last update
5/22/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 2 Veggie Capsules
Amount Per Serving
%DV
Lutein (from 40mg OptiLut® lutein esters extracted from marigold flower, (Tagetes erecta))
20 mg
†
Trans-Zeaxanthin (from OptiLut® marigold flower ext., (Tagetes erecta))
2 mg
†
Top Medical Research Studies
8
Lutein shows promise for heart health
We examined the potential of lutein to protect against heart damage caused by myocardial infarction, using a model induced by isoprenaline. The study showed that pretreating rats with lutein significantly reduced heart injury markers and improved heart function compared to untreated individuals.
Notably, lutein not only decreased damaged heart cells but also positively influenced several protective pathways at the molecular level. However, while the results are promising, they indicate that further research is necessary to fully understand lutein's role in heart health.
Notably, lutein not only decreased damaged heart cells but also positively influenced several protective pathways at the molecular level. However, while the results are promising, they indicate that further research is necessary to fully understand lutein's role in heart health.
9
Lutein shows potential heart benefits
We explored the heart-protective effects of lutein in a study using a rat model of heart failure induced by isoproterenol.
Healthy male rats were divided into four groups receiving different treatments, including lutein.
Results showed that lutein significantly reduced heart damage and inflammation markers while boosting antioxidant defenses. It also improved heart tissue structure. While the findings are promising, further research is needed to confirm lutein's benefits in human heart disease.
Healthy male rats were divided into four groups receiving different treatments, including lutein.
Results showed that lutein significantly reduced heart damage and inflammation markers while boosting antioxidant defenses. It also improved heart tissue structure. While the findings are promising, further research is needed to confirm lutein's benefits in human heart disease.
8
We examined how lutein, a powerful antioxidant, could potentially protect the heart from damage during ischemia-reperfusion injury. By developing a specialized delivery system for lutein, we injected it into rats to see if it could improve mitochondrial function.
Our findings suggested that the antioxidant properties of lutein helped restore mitochondrial health and reduce cell death in heart tissues. However, while we observed promising results regarding mitochondrial function, the overall benefit of lutein treatment on heart disease requires further investigation to fully understand its effectiveness.
Our findings suggested that the antioxidant properties of lutein helped restore mitochondrial health and reduce cell death in heart tissues. However, while we observed promising results regarding mitochondrial function, the overall benefit of lutein treatment on heart disease requires further investigation to fully understand its effectiveness.
Most Useful Reviews
9
Eased discomfort
15 people found this helpful
Suffering from severe dry eyes and presbyopia, I found daily small letter reading had become unbearable. Despite various eye drops providing temporary relief, symptoms worsened with age. Upon starting lutein, I felt relief just three days in, with less discomfort during reading and overall improved clarity. I am encouraged and grateful for this supplement, and my symptoms have eased considerably.
7.5
Eye health improvement
1 people found this helpful
My eyesight improved within a week of taking this product. When I go out, I can clearly see the characters on the signboard, making it easier to focus. I will continue to use it to prevent eye diseases.
7.5
Dry eyes alleviated
1 people found this helpful
After my father took it, his dry eye condition improved significantly. Lutein offers various proven benefits, such as enhancing brain health, cognitive function, and stress resistance. It also reduces the incidence of cardiovascular diseases. Additionally, lutein is linked to improved visual adaptability and offers protection against eye diseases.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.6
- All Researches
9
Innovative lutein delivery for heart health
We investigated a new method of delivering lutein, a potential treatment for hypertensive heart disease. Using biomimetic nanoparticles cloaked in macrophage membranes, we analyzed their ability to target and treat cardiac fibrosis in a specific model.
Our results showed that these nanoparticles not only improved heart function but also reduced fibrosis effectively. Notably, they did this without causing any harmful side effects. Overall, this innovative delivery system could make lutein a more viable option for managing heart diseases linked to pressure overload.
Our results showed that these nanoparticles not only improved heart function but also reduced fibrosis effectively. Notably, they did this without causing any harmful side effects. Overall, this innovative delivery system could make lutein a more viable option for managing heart diseases linked to pressure overload.
9
Lutein shows potential heart benefits
We explored the heart-protective effects of lutein in a study using a rat model of heart failure induced by isoproterenol.
Healthy male rats were divided into four groups receiving different treatments, including lutein.
Results showed that lutein significantly reduced heart damage and inflammation markers while boosting antioxidant defenses. It also improved heart tissue structure. While the findings are promising, further research is needed to confirm lutein's benefits in human heart disease.
Healthy male rats were divided into four groups receiving different treatments, including lutein.
Results showed that lutein significantly reduced heart damage and inflammation markers while boosting antioxidant defenses. It also improved heart tissue structure. While the findings are promising, further research is needed to confirm lutein's benefits in human heart disease.
8
We examined the connection between serum carotenoid levels, including lutein, and cardiovascular-kidney-metabolic syndrome in a diverse group of adult participants. Analyzing data from the NHANES 2017-2018, we discovered that higher serum levels of lutein/zeaxanthin corresponded with a reduced risk of advanced CKM syndrome. In fact, those in the highest quartile for lutein showed a significant odds ratio of 0.26, indicating a strong inverse relationship with disease prevalence.
Overall, our findings suggest that increasing carotenoid levels might contribute to better heart health.
Overall, our findings suggest that increasing carotenoid levels might contribute to better heart health.
8
We examined how lutein, a powerful antioxidant, could potentially protect the heart from damage during ischemia-reperfusion injury. By developing a specialized delivery system for lutein, we injected it into rats to see if it could improve mitochondrial function.
Our findings suggested that the antioxidant properties of lutein helped restore mitochondrial health and reduce cell death in heart tissues. However, while we observed promising results regarding mitochondrial function, the overall benefit of lutein treatment on heart disease requires further investigation to fully understand its effectiveness.
Our findings suggested that the antioxidant properties of lutein helped restore mitochondrial health and reduce cell death in heart tissues. However, while we observed promising results regarding mitochondrial function, the overall benefit of lutein treatment on heart disease requires further investigation to fully understand its effectiveness.
8
In examining the relationship between serum carotenoids, including lutein, and cardiovascular disease (CVD), we analyzed data from over 12,000 adults in the U.S. from the NHANES survey. Our findings revealed that higher levels of carotenoids, particularly lutein, were linked to a lower risk of heart disease.
Specifically, lutein was noted to significantly reduce the prevalence of heart attacks and stroke. This suggests that increasing our intake of carotenoid-rich foods might help in preventing heart-related issues.
Specifically, lutein was noted to significantly reduce the prevalence of heart attacks and stroke. This suggests that increasing our intake of carotenoid-rich foods might help in preventing heart-related issues.
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eased discomfort
15 people found this helpful
Suffering from severe dry eyes and presbyopia, I found daily small letter reading had become unbearable. Despite various eye drops providing temporary relief, symptoms worsened with age. Upon starting lutein, I felt relief just three days in, with less discomfort during reading and overall improved clarity. I am encouraged and grateful for this supplement, and my symptoms have eased considerably.
7.5
Eye health improvement
1 people found this helpful
My eyesight improved within a week of taking this product. When I go out, I can clearly see the characters on the signboard, making it easier to focus. I will continue to use it to prevent eye diseases.
7.5
Dry eyes alleviated
1 people found this helpful
After my father took it, his dry eye condition improved significantly. Lutein offers various proven benefits, such as enhancing brain health, cognitive function, and stress resistance. It also reduces the incidence of cardiovascular diseases. Additionally, lutein is linked to improved visual adaptability and offers protection against eye diseases.
7.5
Improved eye comfort
4 people found this helpful
Since I began taking lutein, my eyes feel considerably better. The dryness I experienced at night has eased, and light sensitivity has significantly improved, suggesting it plays a key role in overall eye health. This supplement has been transformative!
6
Prevents macular degeneration
6 people found this helpful
Lutein effectively absorbs blue light and has antioxidant properties, potentially safeguarding the macula. For those frequently viewing screens, lutein supplementation is recommended. I typically take 10 mg daily, consumed after meals for better absorption. Continuous intake over months maximises the effects due to lutein's presence in the bloodstream. I appreciate this supplement’s role in preventing age-related macular degeneration, supporting our eyes' long-term health.
Frequently Asked Questions
9
Eased discomfort
15 people found this helpful
Suffering from severe dry eyes and presbyopia, I found daily small letter reading had become unbearable. Despite various eye drops providing temporary relief, symptoms worsened with age. Upon starting lutein, I felt relief just three days in, with less discomfort during reading and overall improved clarity. I am encouraged and grateful for this supplement, and my symptoms have eased considerably.
7.5
Eye health improvement
1 people found this helpful
My eyesight improved within a week of taking this product. When I go out, I can clearly see the characters on the signboard, making it easier to focus. I will continue to use it to prevent eye diseases.
7.5
Dry eyes alleviated
1 people found this helpful
After my father took it, his dry eye condition improved significantly. Lutein offers various proven benefits, such as enhancing brain health, cognitive function, and stress resistance. It also reduces the incidence of cardiovascular diseases. Additionally, lutein is linked to improved visual adaptability and offers protection against eye diseases.
6
Prevents macular degeneration
6 people found this helpful
Lutein effectively absorbs blue light and has antioxidant properties, potentially safeguarding the macula. For those frequently viewing screens, lutein supplementation is recommended. I typically take 10 mg daily, consumed after meals for better absorption. Continuous intake over months maximises the effects due to lutein's presence in the bloodstream. I appreciate this supplement’s role in preventing age-related macular degeneration, supporting our eyes' long-term health.
8
In examining the relationship between serum carotenoids, including lutein, and cardiovascular disease (CVD), we analyzed data from over 12,000 adults in the U.S. from the NHANES survey. Our findings revealed that higher levels of carotenoids, particularly lutein, were linked to a lower risk of heart disease.
Specifically, lutein was noted to significantly reduce the prevalence of heart attacks and stroke. This suggests that increasing our intake of carotenoid-rich foods might help in preventing heart-related issues.
Specifically, lutein was noted to significantly reduce the prevalence of heart attacks and stroke. This suggests that increasing our intake of carotenoid-rich foods might help in preventing heart-related issues.
7
We investigated the impact of lutein, a powerful carotenoid, on cardiac microvascular dysfunction linked to heart conditions. Our focus centered on how lutein affects ferroptosis—a type of cell death—in cardiac microvascular endothelial cells.
Results showed that lutein effectively boosted the expression of a key transcription factor called IRF, which offers protection against cell damage during pressure overload. By enhancing IRF levels, lutein appears to help preserve healthy endothelial function in the heart.
While these findings are promising, more studies are needed to fully confirm lutein’s benefits on heart disease.
Results showed that lutein effectively boosted the expression of a key transcription factor called IRF, which offers protection against cell damage during pressure overload. By enhancing IRF levels, lutein appears to help preserve healthy endothelial function in the heart.
While these findings are promising, more studies are needed to fully confirm lutein’s benefits on heart disease.
9
Lutein shows potential heart benefits
We explored the heart-protective effects of lutein in a study using a rat model of heart failure induced by isoproterenol.
Healthy male rats were divided into four groups receiving different treatments, including lutein.
Results showed that lutein significantly reduced heart damage and inflammation markers while boosting antioxidant defenses. It also improved heart tissue structure. While the findings are promising, further research is needed to confirm lutein's benefits in human heart disease.
Healthy male rats were divided into four groups receiving different treatments, including lutein.
Results showed that lutein significantly reduced heart damage and inflammation markers while boosting antioxidant defenses. It also improved heart tissue structure. While the findings are promising, further research is needed to confirm lutein's benefits in human heart disease.
7
We examined how lutein, a carotenoid known for its antioxidant properties, impacts inflammation in those with coronary artery disease (CAD). Our study involved measuring levels of lutein and other carotenoids in blood samples from CAD patients.
Further, we tested the anti-inflammatory effects of lutein on blood cells from these patients. We found that higher lutein levels were linked to lower inflammation markers. Overall, our results suggest that lutein might help reduce chronic inflammation associated with CAD.
Further, we tested the anti-inflammatory effects of lutein on blood cells from these patients. We found that higher lutein levels were linked to lower inflammation markers. Overall, our results suggest that lutein might help reduce chronic inflammation associated with CAD.
References
- Chen M, Cai S, Jia Q, Suo Y, Tang Y, et al. Inverse Relationship Between Serum Carotenoid Levels and Cardiovascular-Kidney-Metabolic Syndrome Among the General Adult Population. J Diabetes. 2025;17:e70046. 10.1111/1753-0407.70046
- Gür FM, Bilgiç S, Aktaş İ. Lutein, a non-provitamin A carotenoid, reduces cisplatin-induced cardiotoxicity. Prostaglandins Other Lipid Mediat. 2025;177:106965. 10.1016/j.prostaglandins.2025.106965
- Shi P, Sha Y, Wang X, Yang T, Wu J, et al. Targeted Delivery and ROS-Responsive Release of Lutein Nanoassemblies Inhibit Myocardial Ischemia-Reperfusion Injury by Improving Mitochondrial Function. Int J Nanomedicine. 2024;19:11973. 10.2147/IJN.S488532
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. 10.2147/CIA.S461821
- Liu Y, Yang G, Huo S, Wu J, Ren P, et al. Lutein suppresses ferroptosis of cardiac microvascular endothelial cells via positive regulation of IRF in cardiac hypertrophy. Eur J Pharmacol. 2023;959:176081. 10.1016/j.ejphar.2023.176081
- Guo T, Chen L, Li F, Cao Y, Li D, et al. Biomimetic nanoparticles loaded lutein functionalized by macrophage membrane for targeted amelioration pressure overload-induced cardiac fibrosis. Biomed Pharmacother. 2023;167:115579. 10.1016/j.biopha.2023.115579
- Wang M, Tang R, Zhou R, Qian Y, Di D. The protective effect of serum carotenoids on cardiovascular disease: a cross-sectional study from the general US adult population. Front Nutr. 2023;10:1154239. 10.3389/fnut.2023.1154239
- Abdelmonem M, Ibrahim SM, Essam RM, Amin HAA, Abd-Elmawla MA. Lutein exerts its cardioprotective effect against the experimental model of isoprenaline-induced myocardial infarction via MIAT/miR-200a/Nrf2/TXINP pathway. J Biochem Mol Toxicol. 2021;35:e22899. 10.1002/jbt.22899
- Chen Y, Wang L, Huang S, Ke J, Wang Q, et al. Lutein attenuates angiotensin II- induced cardiac remodeling by inhibiting AP-1/IL-11 signaling. Redox Biol. 2021;44:102020. 10.1016/j.redox.2021.102020
- Li N, Wu X, Zhuang W, Xia L, Chen Y, et al. Green leafy vegetable and lutein intake and multiple health outcomes. Food Chem. 2021;360:130145. 10.1016/j.foodchem.2021.130145
- Wang L, Tao L, Hao L, Stanley TH, Huang KH, et al. A Moderate-Fat Diet with One Avocado per Day Increases Plasma Antioxidants and Decreases the Oxidation of Small, Dense LDL in Adults with Overweight and Obesity: A Randomized Controlled Trial. J Nutr. 2020;150:276. 10.1093/jn/nxz231
- Ouyang B, Li Z, Ji X, Huang J, Zhang H, et al. The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway. Pharm Biol. 2019;57:529. 10.1080/13880209.2019.1649436
- Chung RWS, Leanderson P, Lundberg AK, Jonasson L. Lutein exerts anti-inflammatory effects in patients with coronary artery disease. Atherosclerosis. 2017;262:87. 10.1016/j.atherosclerosis.2017.05.008
- Leermakers ET, Darweesh SK, Baena CP, Moreira EM, Melo van Lent D, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr. 2016;103:481. 10.3945/ajcn.115.120931
